How Does Peripheral Artery Disease Affect Diabetes?

How Does Peripheral Artery Disease Affect Diabetes
Abstract – Peripheral arterial disease (PAD) refers to partial or complete occlusion of the peripheral vessels of the upper and lower limbs. It usually occurs as part of systemic atherosclerosis in the coronary and cerebral arteries. The prevalence of PAD is expected to continue to increase in the foreseeable future owing to the rise in the occurrence of its major risk factors.

Nonhealing ulcers, limb amputation and physical disability are some of its major complications. Diabetes mellitus (DM) remains a major risk for PAD, with DM patients having more than two-fold increased prevalence of PAD compared with the general population. The clinical presentation in people with DM also differs slightly from that in the general population.

In addition, PAD in DM may lead to diabetic foot ulcers (DFUs), which precipitate hyperglycaemic emergencies and result in increased hospital admissions, reduced quality of life, and mortality. Despite the epidemiological and clinical importance of PAD, it remains largely under diagnosed and hence undertreated, possibly because it is largely asymptomatic.

  1. Emphasis has been placed on neuropathy as a cause of DFUs, however PAD is equally important.
  2. This review examines the epidemiology, pathophysiology and diagnosis of lower limb PAD in people with diabetes and relates these to the general population.
  3. It also highlights recent innovations in the management of PAD.

Keywords: Diabetes, Peripheral arterial disease, Diabetic foot ulcers, Lower limb complications Core Tip: Peripheral arterial disease (PAD) is a major cause of nonhealing ulcers, lower limb amputation and mortality, especially in people with diabetes.

How is peripheral artery disease related to diabetes?

How Do PAD and Diabetes Affect Each Other? – PAD raises your risk for diabetes, and diabetes raises your risk for PAD. Even certain symptoms of each disease raise your risk for the other. Some of these symptoms include:

Inflammation, The levels of certain proteins go up in your body when you have inflammation. These proteins are higher both when you have PAD and when you have diabetes.Cell changes. Diabetes affects the lining around cells in your blood vessels. This means your blood vessels aren’t as flexible as they need to be to help blood flow smoothly. That makes your risk of PAD go up.Blood clotting. When you have diabetes, your blood platelets (disk-shaped cells that help with clotting) clump together more often. This speeds up the process that can cause PAD. Insulin resistance. Diabetes means your body doesn’t respond the right way to insulin. That throws off the balance of chemicals and other substances coming in and out of the cells that line your blood vessels. These cells can’t work as well as they should, which increases your chances of PAD.

About 20%-30% of people diagnosed with PAD also have diabetes. The real number may be even higher because some people don’t have symptoms. Diabetes not only raises your risk of getting PAD, it also can worsen symptoms and bring them on more quickly. Some things that make it more likely you’ll get PAD are out of your control. These include:

Age (Your risk jumps from 20% at age 40 to 29% at age 50)How long you’ve had diabetes Nerve damage Race (Hispanic and African American people with diabetes are at higher risk than white people) Family history of PAD or heart disease

But you do have some control over other things that can raise your chances for PAD. These include:

Being overweight Not exercising Smoking High blood pressure High LDL cholesterol

What happens to peripheral arteries of diabetics?

Overview Peripheral arterial disease (PAD) happens when buildup on the walls of blood vessels causes them to narrow. It commonly affects people with type 2 diabetes, who are also prone to high cholesterol and heart disease. According to the American Diabetes Association, about 1 in 3 people with diabetes over the age of 50 have PAD.

Is PAD associated with diabetes?

1 ) WHAT IS THE EPIDEMIOLOGY AND IMPACT OF PERIPHERAL ARTERIAL DISEASE IN PEOPLE WITH DIABETES? – PAD is a manifestation of atherosclerosis characterized by atherosclerotic occlusive disease of the lower extremities and is a marker for atherothrombotic disease in other vascular beds. PAD affects ∼12 million people in the U.S.; it is uncertain how many of those have diabetes. Data from the Framingham Heart Study (1) revealed that 20% of symptomatic patients with PAD had diabetes, but this probably greatly underestimates the prevalence, given that many more people with PAD are asymptomatic rather than symptomatic. As well, it has been reported that of those with PAD, over one-half are asymptomatic or have atypical symptoms, about one-third have claudication, and the remainder have more severe forms of the disease (2). The most common symptom of PAD is intermittent claudication, defined as pain, cramping, or aching in the calves, thighs, or buttocks that appears reproducibly with walking exercise and is relieved by rest. More extreme presentations of PAD include rest pain, tissue loss, or gangrene; these limb-threatening manifestations of PAD are collectively termed critical limb ischemia (CLI). PAD is also a major risk factor for lower-extremity amputation, especially in patients with diabetes. Moreover, even for the asymptomatic patient, PAD is a marker for systemic vascular disease involving coronary, cerebral, and renal vessels, leading to an elevated risk of events, such as myocardial infarction (MI), stroke, and death. Diabetes and smoking are the strongest risk factors for PAD. Other well-known risk factors are advanced age, hypertension, and hyperlipidemia (3). Potential risk factors for PAD include elevated levels of C-reactive protein (CRP), fibrinogen, homocysteine, apolipoprotein B, lipoprotein(a), and plasma viscosity. An inverse relationship has been suggested between PAD and alcohol consumption. In people with diabetes, the risk of PAD is increased by age, duration of diabetes, and presence of peripheral neuropathy. African Americans and Hispanics with diabetes have a higher prevalence of PAD than non-Hispanic whites, even after adjustment for other known risk factors and the excess prevalence of diabetes. It is important to note that diabetes is most strongly associated with femoral-popliteal and tibial (below the knee) PAD, whereas other risk factors (e.g., smoking and hypertension) are associated with more proximal disease in the aorto-ilio-femoral vessels. The true prevalence of PAD in people with diabetes has been difficult to determine, as most patients are asymptomatic, many do not report their symptoms, screening modalities have not been uniformly agreed upon, and pain perception may be blunted by the presence of peripheral neuropathy. For these reasons, a patient with diabetes and PAD may be more likely to present with an ischemic ulcer or gangrene than a patient without diabetes. While amputation has been used by some as a measure for PAD prevalence, medical care and local indications for amputation versus revascularization of the patient with critical limb ischemia widely vary. The nationwide age-adjusted amputation rate in diabetes is ∼8/1,000 patient years with a prevalence of ∼3%. However, regional patterns differ—there is nearly a ninefold variation of major amputations in people with diabetes across the U.S. Therefore, the incidence and prevalence of amputation may be an imprecise measure of PAD. The reported prevalence of PAD is also affected by the methods by which the diagnosis is sought. Two commonly used tests are the absence of peripheral pulses and the presence of claudication. Both, however, suffer from insensitivity. A more accurate estimation of the prevalence of PAD in diabetes should rely upon a validated and reproducible test. Such a test is the ankle-brachial index (ABI), which involves measuring the systolic blood pressures in the ankles (dorsalis pedis and posterior tibial arteries) and arms (brachial artery) using a hand-held Doppler and then calculating a ratio. Simple to perform, it is a noninvasive, quantitative measurement of the patency of the lower extremity arterial system. Compared with an assessment of pulses or a medical history, the ABI has been found to be more accurate. It has been validated against angiographically confirmed disease and found to be 95% sensitive and almost 100% specific (4). There are some limitations, however, in using the ABI. Calcified, poorly compressible vessels in the elderly and some patients with diabetes may artificially elevate values. The ABI may also be falsely negative in symptomatic patients with moderate aortoiliac stenoses. These issues complicate the evaluation of an individual patient but are not prevalent enough to detract from the usefulness of the ABI as an effective test to screen for and to diagnose PAD in patients with diabetes. Using the ABI, one recent survey (5) found a prevalence of PAD in people with diabetes >40 years of age to be 20%, a prevalence greater than anticipated using less reliable measures, such as symptoms or absent pulses. Moreover, another survey of patients with diabetes >50 years of age showed a prevalence of PAD of 29% (6). Thus, the prevalence of PAD in diabetes appears higher than previously estimated.

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How is diabetes related to PVD?

Abstract – Introduction Diabetes mellitus (DM) is a significant and common risk factor for the development of peripheral vascular disease (PVD). Peripheral vascular disease is the atherosclerotic narrowing of peripheral arteries and has a high prevalence among patients with diabetes. Material and methods A cross-sectional study was conducted in the Department of Medicine of Ayub Teaching Hospital, Abbottabad. A total of 271 diagnosed diabetic patients aged 40 years or above were included in the study. Ankle-brachial pressure index (ABPI) was measured using a hand-held Doppler device and sphygmomanometer. An ABPI < 0.9 was taken to be abnormal. The risk factors were noted through history taking, physical examination, and appropriate investigations. Results Our study sample included 271 patients. A hundred and forty-five (53.5%) of them were males, and 126 (46.5%) were females. Fifty-three (19.9%) out of 271 patients had peripheral vascular disease. The prevalence of peripheral vascular disease was stratified among smoking (p=0.00), hypertension (p=0.00), obesity (p=0.004), and hypercholesterolemia (p=0.005) to determine if there was any association between these and peripheral vascular disease. A p-value less than 0.05 was taken to be significant. Conclusion This study showed a significant association between PVD and smoking, hypertension, hypercholesterolemia, and obesity. Keywords: diabetes mellitus, peripheral vascular disease, smoking, hypertension, hypercholesterolemia, obesity

Why does diabetes increase risk of PVD?

Abstract – The risk of peripheral vascular disease (PVD) is increased in diabetic patients, occurs earlier and is often more severe and diffuse. Endothelial dysfunction, vascular smooth muscle cell dysfunction, inflammation and hypercoagubility are the key factors in diabetic arteriopathy.

The presence of PVD, apart from its increased risk of claudication, ischemic ulcers, gangrene and possible amputation, is also a marker for generalized atherosclerosis and a strong predictor for cardiovascular ischemic events. However, despite the recognition that PVD is associated with increased ischemic event rates and death, particularly in diabetic patients, this specific manifestation of systemic atherosclerosis is largely underdiagnosed and undertreated.

In type-1 diabetes, early intensive insulin treatment reduces both microvascular (nephropathy, retinopathy and neuropathy) and macrovascular complications of diabetes (DCCT/EDIC study). In type-2 diabetes, UKPDS showed that tight glucose control reduces micro- and macrovascular complications, when therapy is started early after diagnosis and that early intervention has long lasting protective effects.

However recently published trials (ADVANCE, ACCORD and VADT) pointed out that lowering glycemic targets to nearly normal glycaemia does not further reduce cardiovascular events in individuals with longstanding type 2 diabetes and that hypoglycaemia is to be avoided in individuals with ischemic heart disease.

Finally, the small but important Steno-2 trial demonstrated that to significantly reduce peripheral vascular disease, ischemic events and mortality in type-2 diabetes, intensified multifactorial treatment of all modifiable risk factors is needed. Therefore, to prevent micro- and macrovascular complications, like PVD, in type-1 and type-2 diabetes, intensive therapy, targeting glycemia and all other modifiable cardiovascular risk factors, should be initiated as soon after diagnosis as possible and maintained in a safe way throughout life.

What is the biggest risk factor for peripheral arterial disease?

Peripheral Arterial Disease | PAD URL of this page: Peripheral arterial disease (PAD) happens when there is a narrowing of the blood vessels outside of your heart. The cause of PAD is, This happens when plaque builds up on the walls of the arteries that supply blood to the arms and legs.

  1. Plaque is a substance made up of fat and cholesterol.
  2. It causes the arteries to narrow or become blocked.
  3. This can reduce or stop blood flow, usually to the legs.
  4. If severe enough, blocked blood flow can cause tissue death and can sometimes lead to amputation of the foot or leg.
  5. The main risk factor for PAD is smoking.

Other risk factors include older age and diseases like diabetes, high blood cholesterol, high blood pressure, heart disease, and stroke. Many people who have PAD don’t have any symptoms. If you have symptoms, they may include:

Pain, numbness, achiness, or heaviness in the leg muscles. This happens when walking or climbing stairs. Weak or absent pulses in the legs or feet Sores or wounds on the toes, feet, or legs that heal slowly, poorly, or not at all A pale or bluish color to the skin A lower temperature in one leg than the other leg Poor nail growth on the toes and decreased hair growth on the legs Erectile dysfunction, especially among men who have diabetes

PAD can increase your risk of,, and, Doctors diagnose PAD with a physical exam and heart and imaging tests. Treatments include lifestyle changes, medicines, and sometimes surgery. Lifestyle changes include dietary changes, exercise, and efforts to lower high levels and, NIH: National Heart, Lung, and Blood Institute

(American Heart Association)

(Vascular Cures)

The information on this site should not be used as a substitute for professional medical care or advice. Contact a health care provider if you have questions about your health. Learn how to cite this page : Peripheral Arterial Disease | PAD

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How does diabetes cause peripheral neuropathy?

What causes diabetic neuropathy? – Over time, high blood glucose levels, also called blood sugar, and high levels of fats, such as triglycerides, in the blood from diabetes can damage your nerves. High blood glucose levels can also damage the small blood vessels that nourish your nerves with oxygen and nutrients. Without enough oxygen and nutrients, your nerves cannot function well.

What is the best treatment for peripheral artery disease?

Medications – If peripheral artery disease (PAD) is causing symptoms, your provider may prescribe medicine. Medications for PAD may include:

Cholesterol drugs. Medications called statins are commonly prescribed for people with peripheral artery disease. Statins help lower bad cholesterol and reduce plaque buildup in the arteries. The drugs also lower the risk of heart attacks and strokes. If you have PAD, ask your provider what your cholesterol numbers should be. Blood pressure drugs. Uncontrolled high blood pressure can make arteries stiff and hard. This can slow the flow of blood. Ask your health care provider what blood pressure goal is best for you. If you have high blood pressure, your provider may prescribe medications to lower it. Medications to control blood sugar. If you have diabetes, controlling your blood sugar levels becomes even more important. Talk with your provider about your blood sugar goals and how to reach them. Medications to prevent blood clots. Peripheral artery disease is related to reduced blood flow to the limbs. So, medicines may be given to improve blood flow. Aspirin or another medication, such as clopidogrel (Plavix), may be used to prevent blood clotting. Medications for leg pain. The drug cilostazol thins the blood and widens blood vessels. It increases blood flow to the limbs. The drug specifically helps treat leg pain in people who have peripheral artery disease. Common side effects of this medication include headache and diarrhea. An alternative medication is pentoxifylline. Side effects are rare with this medication, but it generally doesn’t work as well as cilostazol.

What is the best vitamin for peripheral artery disease?

Current Dietary Guidelines and Recommendations – The 2013 American Heart Association (AHA) and American College of Cardiology composite Task Force guidelines (ACC) 26 address nutrition-focused risk reduction strategies for cardiovascular disease in a broad context, with the aim of improving public health. The guidelines endorse a “Heart Healthy Lifestyle,” 26 and they provide a general framework for incorporating healthy nutrition into lifestyle management to improve blood pressure and lipid control. They emphasize broad nutrient categories that are associated with better cardiovascular outcomes (eg. fruits and vegetables, whole grains, legumes, etc.), although an important limitation is that particular nutrients that may benefit patients with advanced cardiovascular disease are not explicitly identified. The most specific suggestions are embedded in recommendations for lowering low-density lipoprotein cholesterol (LDL-C): the task force advises obtaining a maximum of 5-6% of total calories from saturated fat, reducing dietary monounsaturated fats (e.g., oleic acid found in olive oil), and minimizing intake of foods rich in trans -fats (found in milk, animal fats and some vegetable oils). The AHA/ACC task force guidelines are significant for incorporating the latest high quality clinical trial evidence and promoting preventive strategies for the general population as a means of improving cardiovascular health. However, we remain without specific direction in regards to PAD, a disease at the severe end of the atherosclerotic syndromes. Compared to healthy individuals and those with mild coronary disease, individuals with PAD tend to have a greater systemic inflammatory burden, higher blood pressure, higher triglyceride levels, and deficiencies in various antioxidants and minerals.16, 27 Furthermore, our own experience demonstrates that the mortality rate among patients with PAD is double that of patients with CAD only.28 We, therefore, advocate that beneficial nutrients have a stronger role in cardiovascular risk prevention for people at risk for or with diagnosed PAD. Studies published on nutrition as a means of prevention often have conflicting results and when disseminated in mass media, they may spark confusion about which nutrients are actually beneficial, or which diet is most healthy. The most recent example pertains to reports that saturated fats 29, 30 may have relatively neutral effects on cardiovascular disease, a notion that directly conflicts with the current AHA/ACC guidelines. A more valuable approach in advising patients with PAD would be to promote a diet that is specialized to address the nutritional alterations associated with this condition, and that promotes intake of anti-inflammatory and anti-oxidant rich foods. In fact, recent reports have demonstrated that therapies specifically focused on nutrition and weight reduction in PAD may lead to improvements in functional impairment and ischemic outcomes.16 Nutritional intake and average dietary patterns among patients with PAD have previously been evaluated. Gardner and colleagues 31 demonstrated that PAD and the presence of claudication are associated with a diet high in saturated fat, sodium, and cholesterol and low in fiber, vitamin E, and folate intake. In another study by Antonelli-Incalzi et al., 32 similar patterns were evident: PAD patients were found to have lower consumption of vegetables, fiber, vitamins C and E, folate and long-chain polyunsaturated fatty acids as compared to individuals without PAD. Notably, these cross-sectional studies had relatively small sample sizes and their data was derived from self-reported answers to dietary questionnaires. Despite these limitations, these studies are still instructive and help to inform our understanding of an average nutritional profile in patients with PAD. Larger analyses utilizing population-based data have also been conducted. In their study of the United States National Health and Nutrition Examination Survey (NHANES) data, which included 7,200 patients, Lane et al.21 found that consumption of vitamins A, C, E, B6, and B12 were associated with a lower odds of having PAD. Further analysis indicated that intake of fiber, vitamins A, C, E, B6, folate, and n -3 PUFAs correlated with a reduced prevalence of PAD. Most recently, Naqvi et al.33 analyzed the associations between PAD (ABI< 0.9) and nutrient intake among participants from the NHANES. They found inverse associations between the incidence of PAD and intake of folate, vitamins A, B6, C, and E, affirming the results observed by Lane et al and the smaller cross-sectional studies described previously. However, after adjusting for energy intake and physical activity, odds ratios between the PAD and non-PAD groups were no longer statistically significant. Knowledge about specific nutritional deficiencies can help guide therapeutic efforts. Achieving a better understanding of diet in PAD may also facilitate the design and execution of prospective and randomized trials with clinical outcomes such as major adverse cardiovascular events and limb-related endpoints (e.g. claudication distance, limb revascularization, and amputation). Furthermore, if physicians and health professionals have a better understanding of specific nutrients and their effects on atherosclerotic progression, they can be better equipped to give advice about healthful nutrition. The chief nutrients that have been associated with atherosclerosis include omega-3 polyunsaturated fatty acids ( n -3 PUFAs), folate and B-series vitamins, and anti-oxidants ( Table I ), each of which is reviewed below. Additional nutrients, in particular sodium, saturated fats, and fiber, have also been strongly linked to atherosclerosis risk—these have been extensively evaluated in prior studies in relation to cardiovascular outcomes, are associated with strong (grade I) recommendations from the AHA/ACC and will not be discussed here.34 To identify primary sources, we searched PubMed/Medline and the Cochrane database and we considered studies for inclusion if they were published in 1990 or more recently.

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What triggers peripheral artery disease?

Causes – Peripheral artery disease is often caused by a buildup of fatty, cholesterol-containing deposits (plaques) on artery walls. This process is called atherosclerosis. It reduces blood flow through the arteries. Atherosclerosis affects arteries throughout the body.

Blood vessel inflammation Injury to the arms or legs Changes in the muscles or ligaments Radiation exposure

How does diabetes cause peripheral neuropathy?

What causes diabetic neuropathy? – Over time, high blood glucose levels, also called blood sugar, and high levels of fats, such as triglycerides, in the blood from diabetes can damage your nerves. High blood glucose levels can also damage the small blood vessels that nourish your nerves with oxygen and nutrients. Without enough oxygen and nutrients, your nerves cannot function well.

How does diabetes increase plaque in arteries?

NEW YORK, NY — Type 1 (insulin-dependent) diabetes appears to increase the risk of heart disease, the leading cause of death among people with high blood sugar, partly by stimulating the production of calprotectin, a protein that sparks an inflammatory process that fuels the buildup of artery-clogging plaque.

  1. The findings, made in mice and confirmed with human data, suggest new therapeutic targets for reducing heart disease in people with type 1 diabetes.
  2. Led by Columbia University Medical Center (CUMC) researchers in collaboration with investigators at New York University and the University of Pittsburgh, the study was published today in the online edition of Cell Metabolism.

Diabetes is known to raise the risk for atherosclerosis, a disease in which fatty deposits known as plaque accumulate inside arteries. Over time, the arteries harden and narrow, leading to coronary artery disease and other forms of heart disease. Atherosclerosis is the leading cause of heart attacks, strokes, and peripheral vascular disease—collectively known as coronary heart disease, the leading cause of death in the United States.

Scientists have known that diabetes leads to atherosclerosis. The study shows that this is associated with increased circulating levels of inflammatory white blood cells (WBCs), which contribute to the build-up of plaque. “But exactly how diabetes causes white blood cells to proliferate and lead to heart disease has been a mystery,” said study co-leader Ira J.

Goldberg, MD, the Dickinson W. Richards Professor of Medicine at CUMC. In studies of mice with type 1 diabetes, Dr. Goldberg and his colleagues found that high blood sugar stimulates a type of inflammatory WBC known as neutrophils to release the protein calprotectin (also known as S100A8/9).

The calprotectin travels to the bone marrow, where it binds to a cell-surface receptor called RAGE receptor, on common myeloid progenitor cells, which are involved in the production of various types of blood cells. This, in turn, leads to the proliferation of cells, known as granulocyte macrophage progenitor cells, which trigger the proliferation of even more neutrophils and of monocytes (another type of inflammatory WBC).

Finally, these new WBCs enter the circulation and make their way to arterial plaques, fueling their progression. The researchers also found that normalizing the mice’s blood glucose dampened this pathway, leading to an overall decrease in inflammation.

To determine the relevance of these findings in humans, the researchers analyzed data from 290 patients in the Pittsburgh Epidemiology of Diabetes Complications (EDC) Study, led by EDC Principal Investigator Trevor J. Orchard, who has been following people with diabetes for 18 years. Total WBC, neutrophil, and monocyte counts were all significantly associated with the development of coronary artery disease.

The researchers also analyzed blood samples from a subgroup of EDC patients. Those who had developed coronary artery disease had significantly higher levels of calprotectin, compared with patients who had not developed coronary artery disease. “The human data appear to fit with the animal data, in that both WBCs and calprotectin are associated with heart disease,” said co-lead author Andrew J.

Murphy, PhD, postdoctoral fellow in medicine at CUMC. The other lead author is Prabhakara R. Nagareddy, PhD, postdoctoral fellow at CUMC. “Our findings point to the importance of controlling blood sugar levels to limit the production of the inflammatory cells that drive atherosclerosis; they also suggest novel therapeutic strategies, such as inhibiting the production of calprotectin or preventing its binding to the RAGE receptor,” said study co-leader Alan R.

Tall, MD, the Tilden Weger Bieler Professor of Medicine at CUMC. The CUMC team is currently studying how type 2 diabetes increases one’s risk for heart disease. The paper is titled, “Hyperglycemia promotes myelopoiesis and impairs the resolution of atherosclerosis.” The other contributors are Roslynn A.

Stirzaker (CUMC), Yunying Hu (CUMC), Shiuqing Yu (CUMC), Rachel G. Miller (University of Pittsburgh, Pittsburgh, Penn.), Bhama Ramkhelawon New York University, New York, NY), Emilie Distel (NYU), Marit Westerterp (CUMC), Li-Shin Huang (CUMC), Ann Marie Schmidt (NYU), and Edward A.Fisher (NYU). This research was supported by grants from the National Institutes of Health ( U01-21 HL087945, DK095684 and DK048412 ; and P01 HL54591, and R01 HL107653, a Pilot and Feasibility Award from the Diabetes Complications Consortium, and postdoctoral fellowships from the Canadian Institutes of Health Research and the American Heart Association.

A portion of funds supporting this research was obtained from Bristol-Myers Squibb Pharmaceuticals. The authors declare no other financial or conflicts of interest. #### Columbia University Medical Center provides international leadership in basic, pre-clinical, and clinical research; medical and health sciences education; and patient care.

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